{"pressReleaseArticle":{"contentWrapper":{"title":"Jemperli (dostarlimab-gxly) RUBY phase III trial met its primary endpoint in a planned interim analysis in patients with primary advanced or recurrent endometrial cancer ","intro":"","publishDateTime":"02/12/2022 00:00:00","publishDate":"December 02 2022","forInvestorsAndMediaOnlyText":"<p>Issued: London, UK</p>\r\n<p>For media and investors only</p>","shortDescription":"Results showed a statistically significant and clinically meaningful improvement in investigator-assessed progression-free survival","image":null,"downloadLink":null,"tags":[]},"components":[{"type":"rich-text","text":"<ul>\n<li><strong>Results showed a statistically significant and clinically meaningful improvement in investigator-assessed progression-free survival </strong></li>\n<li><strong>RUBY is the only first-line trial to show improvement in progression-free survival for an immuno-oncology therapy in combination with standard-of-care chemotherapy in primary advanced or recurrent endometrial cancer </strong></li>\n<li><strong>Regulatory submissions based on the trial results are planned for the first half of 2023 </strong></li>\n</ul>\n<p>GSK plc (LSE/NYSE: GSK) today announced positive headline results from the planned interim analysis of Part 1 of the RUBY/ENGOT-EN6/GOG3031/NSGO phase III trial investigating <em>Jemperli</em> (dostarlimab-gxly) plus standard-of-care chemotherapy (carboplatin-paclitaxel) followed by <em>Jemperli</em> compared to chemotherapy plus placebo followed by placebo in adult patients with primary advanced or recurrent endometrial cancer. The trial met its primary endpoint of investigator-assessed progression-free survival (PFS). It showed a statistically significant and clinically meaningful benefit in the prespecified mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) patient subgroup and in the overall population. A clinically relevant benefit in PFS was also observed in the mismatch repair proficient (MMRp)/microsatellite stable (MSS) patient subgroup.</p>\n<p>While the overall survival (OS) data were immature at the time of this analysis, a favorable trend was observed in the overall population, including both the dMMR/MSI-H and MMRp/MSS subgroups.</p>\n<p>The safety and tolerability profile of dostarlimab-gxly in the RUBY phase III trial was consistent with clinical trials of similar regimens. The most common treatment-emergent adverse events in patients receiving dostarlimab-gxly plus chemotherapy were nausea, alopecia, fatigue, peripheral neuropathy, anemia, arthralgia, constipation and diarrhea.</p>\n<p><strong>Hesham Abdullah, Senior Vice President, Global Head of Oncology Development, GSK said: </strong>“Patients with primary advanced or recurrent endometrial cancer have limited treatment options. Long-term outcomes remain poor, and new treatment options are urgently needed to evolve the current standard of care, which is platinum-based chemotherapy. Based on these positive headline results from the RUBY phase III trial, GSK intends to seek regulatory approvals for a potential new indication for dostarlimab-gxly in the treatment of primary advanced or recurrent endometrial cancer.”</p>\n<p>Regulatory submissions based on the trial results are anticipated in the first half of 2023. Full results from the trial will be published in a medical journal and presented at an upcoming scientific meeting.</p>\n<p>RUBY is part of an international collaboration between the European Network of Gynaecological Oncological Trial groups (ENGOT), a research network of the European Society of Gynaecological Oncology (ESGO) that consists of 22 trial groups from 31 European countries that perform cooperative clinical trials, and the GOG Foundation, a non-profit organization dedicated to transforming the standard of care in gynecologic oncology.</p>\n<p><strong>About endometrial cancer</strong></p>\n<p>Endometrial cancer is found in the inner lining of the uterus, known as the endometrium. It is the most common gynecologic cancer in the US and the second most common gynecologic cancer globally.<sup><a name=\"_RUBYref1\" href=\"#_RUBY1\"><span>1</span></a></sup> Approximately 15-20% of women with endometrial cancer will be diagnosed with advanced disease at the time of diagnosis.<sup><a name=\"_RUBYref2\" href=\"#_RUBY2\"><span>2</span></a></sup></p>\n<p><strong>About RUBY</strong></p>\n<p>RUBY is a two-part global, randomized, double-blind, multicenter phase III trial of patients with primary advanced or recurrent endometrial cancer. Part 1 is evaluating dostarlimab-gxly plus carboplatin-paclitaxel followed by dostarlimab-gxly versus carboplatin-paclitaxel plus placebo followed by placebo. Part 2 is evaluating dostarlimab-gxly plus carboplatin-paclitaxel followed by dostarlimab-gxly plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo. The primary endpoints in Part 1 are investigator-assessed PFS based on the Response Evaluation Criteria in Solid Tumors v1.1 and OS. In Part 2, the primary endpoint is investigator-assessed PFS. Secondary endpoints in Part 1 and Part 2 include PFS per blinded independent central review, overall response rate, duration of response, disease control rate, patient-reported outcomes, and safety and tolerability.</p>\n<p><strong>About <em>Jemperli </em>(dostarlimab-gxly) </strong></p>\n<p><em>Jemperli </em>is a programed death receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2.<sup><a name=\"_RUBYref3\" href=\"#_RUBY3\"><span>3</span></a> </sup>Dostarlimab-gxly is being investigated in registrational enabling studies, as monotherapy and as part of combination regimens, including in women with recurrent or primary advanced endometrial cancer, women with Stage III or IV non-mucinous epithelial ovarian cancer, and patients with other advanced solid tumors or metastatic cancers.</p>\n<p>Dostarlimab-glxy was discovered by AnaptysBio and licensed to TESARO, Inc., under a collaboration and exclusive license agreement signed in March 2014. The collaboration has resulted in three monospecific antibody therapies that have progressed into the clinic. These are: dostarlimab-gxly (GSK4057190), a PD-1 antagonist; cobolimab, (GSK4069889), a TIM-3 antagonist; and GSK4074386, a LAG-3 antagonist. GSK is responsible for the ongoing research, development, commercialization, and manufacturing of each of these medicines under the agreement.</p>\n<p><strong>Indications and Important Safety Information for <em>JEMPERLI</em> (dostarlimab-gxly)</strong></p>\n<p><em>JEMPERLI</em> is indicated for the treatment of adult patients with mismatch repair deficient (dMMR) recurrent or advanced:</p>\n<ul>\n<li>endometrial cancer (EC), as determined by an FDA-approved test, that has progressed on or following prior treatment with a platinum-containing regimen, or</li>\n<li>solid tumors, as determined by an FDA-approved test, that have progressed on or following prior treatment and who have no satisfactory alternative treatment options.</li>\n</ul>\n<p>These indications are approved under accelerated approval based on tumor response rate and durability of response. Continued approval for these indications may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).</p>\n<p><strong>Important Safety Information</strong></p>\n<p><strong>Severe and Fatal Immune-Mediated Adverse Reactions </strong></p>\n<ul>\n<li>Immune-mediated adverse reactions, which can be severe or fatal, can occur in any organ system or tissue and can occur at any time during or after treatment with a PD-1/PD-L1–blocking antibody, including <em>JEMPERLI</em>.</li>\n<li>Monitor closely for signs and symptoms of immune-mediated adverse reactions. Evaluate liver enzymes, creatinine, and thyroid function tests at baseline and periodically during treatment. For suspected immune-mediated adverse reactions, initiate appropriate workup to exclude alternative etiologies, including infection. Institute medical management promptly, including specialty consultation as appropriate.</li>\n<li>Based on the severity of the adverse reaction, withhold or permanently discontinue <em>JEMPERLI</em>. In general, if <em>JEMPERLI</em> requires interruption or discontinuation, administer systemic corticosteroids (1 to 2 mg/kg/day prednisone or equivalent) until improvement to ≤Grade 1. Upon improvement to ≤Grade 1, initiate corticosteroid taper and continue to taper over at least 1 month. Consider administration of other systemic immunosuppressants in patients whose immune-mediated adverse reaction is not controlled with corticosteroids.</li>\n</ul>\n<p><strong>Immune-Mediated Pneumonitis </strong></p>\n<ul>\n<li><em>JEMPERLI</em> can cause immune-mediated pneumonitis, which can be fatal. In patients treated with other PD-1/PD-L1–blocking antibodies, the incidence of pneumonitis is higher in patients who have received prior thoracic radiation. Pneumonitis occurred in 1.4% (7/515) of patients, including Grade 2 (1.2%) and Grade 3 (0.2%) pneumonitis.</li>\n</ul>\n<p><strong>Immune-Mediated Colitis</strong></p>\n<ul>\n<li>Colitis occurred in 1.4% (7/515) of patients, including Grade 2 (0.8%) and Grade 3 (0.6%) adverse reactions. Cytomegalovirus infection/reactivation have occurred in patients with corticosteroid-refractory immune-mediated colitis. In such cases, consider repeating infectious workup to exclude alternative etiologies.</li>\n</ul>\n<p><strong>Immune-Mediated Hepatitis</strong></p>\n<ul>\n<li><em>JEMPERLI</em> can cause immune-mediated hepatitis, which can be fatal. Grade 3 hepatitis occurred in 0.2% (1/515) of patients.</li>\n</ul>\n<p><strong>Immune-Mediated Endocrinopathies</strong></p>\n<ul>\n<li>Adrenal Insufficiency\n<ul>\n<li>Adrenal insufficiency occurred in 1.4% (7/515) of patients, including Grade 2 (0.8%) and Grade 3 (0.6%). For Grade 2 or higher adrenal insufficiency, initiate symptomatic treatment per institutional guidelines, including hormone replacement as clinically indicated. Withhold or permanently discontinue <em>JEMPERLI</em> depending on severity.</li>\n</ul>\n</li>\n<li>Hypophysitis\n<ul>\n<li><em>JEMPERLI</em> can cause immune-mediated hypophysitis. Initiate hormone replacement as clinically indicated. Withhold or permanently discontinue <em>JEMPERLI</em> depending on severity.</li>\n</ul>\n</li>\n<li>Thyroid Disorders\n<ul>\n<li>Thyroiditis occurred in 0.4% (2/515) of patients; both were Grade 2. Hypothyroidism occurred in 7.2% (37/515) of patients, all of which were Grade 2. Hyperthyroidism occurred in 1.9% (10/515) of patients, including Grade 2 (1.7%) and Grade 3 (0.2%). Initiate hormone replacement or medical management of hyperthyroidism as clinically indicated. Withhold or permanently discontinue <em>JEMPERLI</em> depending on severity.</li>\n</ul>\n</li>\n<li>Type 1 Diabetes Mellitus, Which Can Present with Diabetic Ketoacidosis\n<ul>\n<li><em>JEMPERLI</em> can cause type 1 diabetes mellitus, which can present with diabetic ketoacidosis. Monitor patients for hyperglycemia or other signs and symptoms of diabetes. Initiate treatment with insulin as clinically indicated. Withhold or permanently discontinue <em>JEMPERLI</em> depending on severity.</li>\n</ul>\n</li>\n</ul>\n<p><strong>Immune-Mediated Nephritis with Renal Dysfunction</strong></p>\n<ul>\n<li><em>JEMPERLI</em> can cause immune-mediated nephritis, which can be fatal. Nephritis occurred in 0.4% (2/515) of patients; both were Grade 2.</li>\n</ul>\n<p><strong>Immune-Mediated Dermatologic Adverse Reactions</strong></p>\n<ul>\n<li><em>JEMPERLI</em> can cause immune-mediated rash or dermatitis. Bullous and exfoliative dermatitis, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), have occurred with PD-1/PD-L1–blocking antibodies. Topical emollients and/or topical corticosteroids may be adequate to treat mild to moderate non-bullous/exfoliative rashes. Withhold or permanently discontinue <em>JEMPERLI</em> depending on severity.</li>\n</ul>\n<p><strong>Other Immune-Mediated Adverse Reactions </strong></p>\n<p>The following clinically significant immune-mediated adverse reactions occurred in &lt;1% of the 515 patients treated with <em>JEMPERLI</em> or were reported with the use of other PD-1/PD-L1–blocking antibodies. Severe or fatal cases have been reported for some of these adverse reactions.</p>\n<ul>\n<li><em>Nervous System:</em> Meningitis, encephalitis, myelitis and demyelination, myasthenic syndrome/myasthenia gravis, Guillain-Barre syndrome, nerve paresis, autoimmune neuropathy</li>\n<li><em>Cardiac/Vascular:</em> Myocarditis, pericarditis, vasculitis</li>\n<li><em>Ocular:</em> Uveitis, iritis, other ocular inflammatory toxicities. Some cases can be associated with retinal detachment. Various grades of visual impairment to include blindness can occur</li>\n<li><em>Gastrointestinal:</em> Pancreatitis, including increases in serum amylase and lipase levels, gastritis, duodenitis</li>\n<li><em>Musculoskeletal and Connective Tissue:</em> Myositis/polymyositis, rhabdomyolysis and associated sequelae including renal failure, arthritis, polymyalgia rheumatica</li>\n<li><em>Endocrine:</em> Hypoparathyroidism</li>\n<li><em>Other (Hematologic/Immune):</em> Autoimmune hemolytic anemia, aplastic anemia, hemophagocytic lymphohistiocytosis, systemic inflammatory response syndrome, histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis), sarcoidosis, immune thrombocytopenia, solid organ transplant rejection</li>\n</ul>\n<p><strong>Infusion-Related Reactions</strong></p>\n<ul>\n<li>Severe or life-threatening infusion-related reactions have been reported with PD-1/PD-L1–blocking antibodies. Severe infusion-related reactions (Grade 3) occurred in 0.2% (1/515) of patients receiving <em>JEMPERLI</em>. Monitor patients for signs and symptoms of infusion-related reactions. Interrupt or slow the rate of infusion or permanently discontinue <em>JEMPERLI</em> based on severity of reaction.</li>\n</ul>\n<p><strong>Complications of Allogeneic HSCT </strong></p>\n<ul>\n<li>Fatal and other serious complications can occur in patients who receive allogeneic hematopoietic stem cell transplantation (HSCT) before or after treatment with a PD-1/PD-L1–blocking antibody, which may occur despite intervening therapy. Monitor patients closely for transplant-related complications and intervene promptly.</li>\n</ul>\n<p><strong>Embryo-Fetal Toxicity and Lactation </strong></p>\n<ul>\n<li>Based on its mechanism of action, <em>JEMPERLI</em> can cause fetal harm. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with <em>JEMPERLI</em> and for 4 months after their last dose. Because of the potential for serious adverse reactions from <em>JEMPERLI</em> in a breastfed child, advise women not to breastfeed during treatment with <em>JEMPERLI</em> and for 4 months after their last dose.</li>\n</ul>\n<p><strong>Common Adverse Reactions </strong></p>\n<ul>\n<li>The most common adverse reactions (≥20%) in patients with dMMR EC were fatigue/asthenia, nausea, diarrhea, anemia, and constipation. The most common Grade 3 or 4 laboratory abnormalities (≥2%) were decreased lymphocytes, decreased sodium, decreased leukocytes, decreased albumin, increased creatinine, increased alkaline phosphatase, and increased alanine aminotransferase. The most common adverse reactions (≥20%) in patients with dMMR solid tumors were fatigue/asthenia, anemia, diarrhea, and nausea. The most common Grade 3 or 4 laboratory abnormalities (≥2%) were decreased lymphocytes, decreased sodium, increased alkaline phosphatase, and decreased albumin.</li>\n</ul>\n<p><strong>Please see the full <a rel=\"noopener\" href=\"https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Jemperli/pdf/JEMPERLI-PI-MG.PDF\" target=\"_blank\" title=\"Opens in a new window\"> US Prescribing Information. </a></strong></p>\n<p><strong>About GSK </strong></p>\n<p>GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at <a rel=\"noopener\" href=\"https://us.gsk.com/en-us/company/\" target=\"_blank\" title=\"Opens in a new window\">us.gsk.com/en-us/company</a></p>\n<p><strong>References</strong></p>\n<p><a name=\"_RUBY1\" href=\"#_RUBYref1\"><span>[1]</span></a><span> Braun MM, et al. Am Fam Physician. 2016;93(6):468-474. </span></p>\n<p><a name=\"_RUBY2\" href=\"#_RUBYref2\"><span>[2]</span></a><span> Kantar Health, Cust Study (2018).</span></p>\n<p><a name=\"_RUBY3\" href=\"#_RUBYref3\"><span>[3]</span></a><span> Laken H, Kehry M, Mcneeley P, et al. Identification and characterization of TSR-042, a novel anti-human PD-1 therapeutic antibody. European Journal of Cancer. 2016;69,S102. doi:10.1016/s0959-8049(16)32902-1.</span></p>","useGreyBackground":false,"fullWidth":false}]},"id":5308,"docCheckLogout":null,"pageType":"pressReleasePage","languageCode":"en-US","theme":"light","breadcrumb":{"ariaLabel":"Breadcrumb","links":[{"text":"Home","href":"/en-us/","openInNewWindowText":null},{"text":"Media","href":"/en-us/media/","openInNewWindowText":null},{"text":"Press releases","href":"/en-us/media/press-releases/","openInNewWindowText":null},{"text":"Jemperli (dostarlimab-gxly) RUBY phase III trial met its primary endpoint in a planned interim analysis in patients with primary advanced or recurrent endometrial cancer ","href":"/en-us/media/press-releases/jemperli-dostarlimab-gxly-ruby-phase-iii-trial-met-its-primary-endpoint-in-a-planned-interim-analysis-in-patients-with-primary-advanced-or-recurrent-endometrial-cancer/","openInNewWindowText":null}]},"pageName":"Jemperli (dostarlimab-gxly) RUBY phase III trial met its primary 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