{"magazineArticle":{"contentWrapper":{"hideReadArticle":false,"headline":"Immuno-Oncology: Integrating innovation into standard of care practice","datePublished":"2020-05-27T00:00:00","datePublishedFormatted":"May 27 2020","parentHref":{"text":"Behind the Science US edition","href":"/en-us/behind-the-science-us-edition/","openInNewWindowText":null},"nextArticle":{"text":"Next article","href":"/en-us/behind-the-science-us-edition/linking-a-chapter-of-gsk-history-for-seeking-freedom/","openInNewWindowText":null},"carouselTitle":"","readTimeMins":1,"captions":{"listenToArticle":"Listen to this article","readTime":"min read time","relatedTags":"Related tags"},"heroImage":{"src":"/media/projl1zi/scientist-2.jpg?format=webp&v=1dbe1225319d0a0&hmac=7c3875c002508a93624e7eb365d2c11a0957ec50f1831416264f86fcbc0eae2b","alt":"Female working in lab.","darkModeSrc":"/media/projl1zi/scientist-2.jpg?format=webp&quality=90&v=1dbe1225319d0a0&hmac=9d72771557b707c0ef7735f977d6fab237cded4dc73b9109df3267f41edd6f88"},"author":null,"articleType":"Editorial","videoType":null,"topics":["Innovation"],"introText":""},"components":[{"type":"rich-text","text":"

The field of immuno-Oncology (I-O) was revolutionised with the discovery of T-cell immune checkpoints CTLA-4 and PD-1. Blocking these brought about a number of autoimmune adverse events, but with it an enhanced immune response against tumours. These results confirmed that tumours suppress the immune system as a mechanism to ensure their survival, and led to the hypothesis that the immune system could be mobilised to control many cancers affecting a variety of cells and tissues.[3,4]

\n

Ongoing clinical trials are assessing the potential of other immune checkpoints as researchers look for ways to overcome immune checkpoint toxicity.[3] Other active areas of I-O research are searching for new ways to target tumours through understanding their surrounding microenvironment, including investigating the potential of ‘metabolic checkpoints’, and understanding the influence of the patient’s microbiome on response to immunotherapy.[3]

\n

The immune system is now known to recognise and respond to tumours through a process known as immunosurveillance.[5] The immune system uses the recognition of viral or mutated proteins expressed on the tumour surface – tumour antigens – to do this.[5] However, tumours have their own immunosuppressive mechanisms that make these initial immune responses ineffective.[5]

\n

I-O therapies, ranging from monoclonal antibodies to cellular vaccines, stimulate or inhibit particular immune checkpoints in order to boost the patient’s own anti-tumour immune responses.[3,6,7] This method differs from ‘targeted’ therapies, which target the tumour directly or aim to disrupt the tumour blood supply, as well as traditional chemo- and radiation therapies which cause ‘collateral’ damage to healthy cells.[4,8,9]

","useGreyBackground":false,"fullWidth":false},{"type":"rich-text","text":"

I-O therapies are the next generation of cancer treatment

\n

In responsive patients, I-O therapy can provide more durable clinical outcomes than traditional therapies such as chemotherapy and radiotherapy and, in some cases contribute to complete tumour regression. I-O therapies also pose less detrimental impact on patients’ quality of life due to a lower incidence of serious adverse events.[10]

\n

However, not all patients respond to I-O therapies. There is the issue of tumour heterogeneity; cancer cells within a tumour that mutate over time into potentially different sub-populations with different levels of sensitivity to anticancer therapies.[11] There are also many naturally occurring pathways in place to prevent autoimmunity in the human body, which can limit the effectiveness of these therapies.

\n

GSK is developing cancer immunotherapies that are designed to target these regulatory pathways as a means of improving response rates in cancer patients.

","useGreyBackground":false,"fullWidth":false},{"type":"rich-text","text":"

Solidifying I-O into standard of care practice

\n

Unlike traditional therapies, I-O therapies are able to induce durable immune responses to cancer cells in responsive patients partly due to the mechanism of immunological memory. This means that the immune system can mount a more intense response when encountering a tumour antigen a second time.[12]

\n

The observation that I-O therapies have the potential to extend the lives of patients beyond that of traditional therapies is shifting the focus of clinical trials from improvements in typical measures such as progression-free survival and median overall survival, to the more gold-standard measure of overall survival extension (e.g. 2- or 5-year survival rates).[12]

\n

I-O is becoming increasingly established in standard of care practice as results of combination clinical trials are published. These studies examine strategies to combine synergistic I-O therapies or I-O in combination with traditional and/or ‘targeted’ therapies. The improvements in outcomes may however come at the cost of increased drug-related toxicities.[12]

","useGreyBackground":false,"fullWidth":false},{"imageOnLeft":false,"image":{"src":"/media/swdj3c3w/immuno-oncology-science-image-2.jpg?width=624&height=416&format=webp&quality=100&v=1dbe1227ca8b350&hmac=72756ce858efc0301b2f7ef59813c3da83a84f6714cdbfb27d7156b9e2c5b7d6","alt":"Oncology 3D photo","darkModeSrc":"/media/swdj3c3w/immuno-oncology-science-image-2.jpg?width=624&height=416&format=webp&quality=90&v=1dbe1227ca8b350&hmac=0370b14ae7ece8f7c913b6d37fddfe51bdf027a21bf229425a010ca6750d0271"},"imageCaption":"","text":"

GSK is ambitious in the pursuit of I-O innovation

\n

At GSK, we are at the forefront of innovation in R&D, building on first- and second-generation I-O research.

\n

We have made significant investments in genetics and functional genomics, for example through our partnerships with 23andMe and the Laboratory of Genomics Research. Together, we are helping to identify novel genetically validated targets and to progress critical path biology through early drug discovery, delivering promising clinical candidates for Phase I studies.

\n

GSK has made a commitment to develop transformative medicines for cancer patients and we will continue to advance our understanding of Immuno-Oncology to deliver on our promise.

","greyBackground":false,"orangeLink":null,"header":"","type":"text-and-image","ariaHidden":false},{"type":"rich-text","text":"

References

\n

[1] McCarthy EF. The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J 2006;26:154.

\n

[2] Cornejo CM, Haun P, English III J, et al. Immune checkpoint inhibitors and the development of granulomatous reactions. J Am Acad Dermatol 2019;81(5):1165-75.

\n

[3] Esfahani K, Roudaia L, Buhlaiga N, et al. A review of cancer immunotherapy: from the past, to the present, to the future. Curr Oncol 2020;27(S2).

\n

[4] Dempke WC, Fenchel K, Uciechowski P, Dale SP. Second-and third-generation drugs for immuno-oncology treatment—the more the better?. Eur J Cancer 2017;74:55-72.

\n

[5] Finn OJ. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Ann Oncol 2012;23(S8):viii6-9.

\n

[6] Adams JL, Smothers J, Srinivasan R et al. Big opportunities for small molecules in immuno-oncology Nat Rev Drug Discov 2015;14(9):603-22.

\n

[7] Hoos A, Britten CM. The immuno-oncology framework: Enabling a new era of cancer therapy. Oncoimmunology 2012 May 1;1(3):334-9.

\n

[8] Bagnyukova TV, Serebriiskii IG, Zhou Y, et al. Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?. Cancer Biol Ther 2010 Nov 1;10(9):839-53.

\n

[9] Baskar R, Dai J, Wenlong N, et al. Biological response of cancer cells to radiation treatment. Front Mol Biosci 2014 Nov 17;1:24.

\n

[10] Kaufman HL, Atkins MB, Subedi P, et al. The promise of Immuno-oncology: implications for defining the value of cancer treatment. J Immunother Cancer 2019;7(1):129.

\n

[11] Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol 2018 Feb;15(2):81.

\n

[12] Harris SJ, Brown J, Lopez J, et al. Immuno-oncology combinations: raising the tail of the survival curve. Cancer Biol Med 2016;13(2):171.

","useGreyBackground":false,"fullWidth":false},{"type":"varied-signpost-grid","title":"You might also like","layoutPattern":4,"pages":[{"title":"Are they the same? Atlantic City and your color TV","content":"In 1949, Smith Kline & French Laboratories (now GSK) invested in the promise of color television through a partnership with the CBS network","image":{"src":"/media/k1upue1n/nj_atlantic-city_color-tv-3.jpg?width=427&height=533&format=webp&quality=100&v=1dbe1224bbe6c30&hmac=a341f66f8ab1ade1759f34ea3c3800333aea2c0b3c3b303fdfb43cf84aed0af1","alt":"Nj Atlantic City Color Tv","darkModeSrc":"/media/k1upue1n/nj_atlantic-city_color-tv-3.jpg?width=427&height=533&format=webp&quality=90&v=1dbe1224bbe6c30&hmac=9cf7c2d5c7f30927b4fd9aa22882371448602fdaf84bf7fde07af74d6370e3c2"},"link":{"text":"Are they the same? Atlantic City and your color TV","href":"/en-us/behind-the-science-us-edition/are-they-the-same-atlantic-city-and-your-color-tv/","openInNewWindowText":null}},{"title":"Synthetic Lethality: outmaneuvering the cancer genome","content":"Synthetic lethality is a new strategy for developing anticancer therapies","image":{"src":"/media/b2xb2c4f/gsk_dna_6k_still-2.png?width=427&height=533&format=webp&quality=100&v=1dbe122828fee50&hmac=ea27bc195816ef6086cd8345ef915609c43913e8999626f9cb4d3c016ffea632","alt":"DNA strand ","darkModeSrc":"/media/b2xb2c4f/gsk_dna_6k_still-2.png?width=427&height=533&format=webp&quality=90&v=1dbe122828fee50&hmac=2973230865c134ab497832d77eeb1e3c31c2ce8ed0ef13363fa9444c8b0acc82"},"link":{"text":"Synthetic Lethality: outmaneuvering the cancer genome","href":"/en-us/behind-the-science-us-edition/synthetic-lethality-outmaneuvering-the-cancer-genome/","openInNewWindowText":null}},{"title":"Innovation","content":"Prevention is about innovating to change the course of disease.","image":{"src":"/media/p03dcneu/innovation-landing-header-scientist-at-computer-01.jpg?width=427&height=533&format=webp&quality=100&v=1dcbc35a7e280c0&hmac=793c6083016b0da481f7033e97a4fd57bfdc552bd195b3a478fcf8f92c021919","alt":"Scientist at a computer monitor looking at 3D images in high throughput screening lab ","darkModeSrc":"/media/p03dcneu/innovation-landing-header-scientist-at-computer-01.jpg?width=427&height=533&format=webp&quality=90&v=1dcbc35a7e280c0&hmac=707391076d738721ba8848ac8d0b573dbf9151446a1f7a3611de09b2e0d71fca"},"link":{"text":"Innovation","href":"/en-us/innovation/","openInNewWindowText":null}}],"hidePageDescription":false,"useGreyBackground":false}]},"id":5183,"docCheckLogout":null,"pageType":"magazinePage","languageCode":"en-US","theme":"light","breadcrumb":{"ariaLabel":"Breadcrumb","links":[{"text":"Home","href":"/en-us/","openInNewWindowText":null},{"text":"Behind the Science US edition","href":"/en-us/behind-the-science-us-edition/","openInNewWindowText":null},{"text":"Immuno-Oncology: Integrating innovation into standard of care practice","href":"/en-us/behind-the-science-us-edition/immuno-oncology-integrating-innovation-into-standard-of-care-practice/","openInNewWindowText":null}]},"pageName":"Immuno-Oncology: Integrating innovation into standard of care practice","topNav":{"homeLink":{"text":"GSK Homepage","href":"/en-us/","openInNewWindowText":null},"topBar":{"currentLocation":{"isGlobal":false,"text":"United States (EN)"},"languageSelector":{"currentLanguage":null,"currentLanguageMobile":null,"selectableLanguages":[]},"darkModeSwitch":{"text":"Dark Mode","tooltipText":"

Switch to dark mode to head towards a more sustainable world together. More info

"},"globalSiteLink":{"text":"Global","href":"https://www.gsk.com","target":"_blank","openInNewWindowText":"Opens in a new window"},"locationSelector":{"text":"Change location","href":"/en-us/locations/","openInNewWindowText":null},"healthCareLink":{"text":"Healthcare professionals","href":"https://gskpro.com","target":"_blank","openInNewWindowText":"Opens in a new window"},"contactUs":{"text":"Contact us","href":"/en-us/contact-us/","openInNewWindowText":null},"search":"Search","backToMain":"Back to main","menu":"Menu","closeMenu":"Close menu","animationsToggleModel":{"enable":true,"activeText":"Pause video","inactiveText":"Play video"}},"nodes":[{"tooltip":null,"hasBorderRight":true,"title":"Behind the Science US edition","url":"/en-us/behind-the-science-us-edition/","nodes":[],"isActive":true,"promos":[]},{"tooltip":null,"hasBorderRight":false,"title":"Company","url":"/en-us/company/","nodes":[{"title":"Purpose, strategy and culture","url":"/en-us/company/purpose-strategy-and-culture/","nodes":[],"isActive":false},{"title":"Respiratory, immunology and inflammation","url":"/en-us/company/respiratory-immunology-and-inflammation/","nodes":[],"isActive":false},{"title":"Oncology","url":"/en-us/company/oncology/","nodes":[{"title":"Myelofibrosis","url":"/en-us/company/oncology/myelofibrosis/","nodes":[],"isActive":false},{"title":"Ovarian cancer","url":"/en-us/company/oncology/ovarian-cancer/","nodes":[],"isActive":false},{"title":"Endometrial cancer","url":"/en-us/company/oncology/endometrial-cancer/","nodes":[],"isActive":false},{"title":"Multiple myeloma","url":"/en-us/company/oncology/multiple-myeloma/","nodes":[],"isActive":false},{"title":"Rectal cancer","url":"/en-us/company/oncology/rectal-cancer/","nodes":[],"isActive":false}],"isActive":false},{"title":"HIV","url":"/en-us/company/hiv/","nodes":[],"isActive":false},{"title":"Infectious diseases","url":"/en-us/company/infectious-diseases/","nodes":[{"title":"Vaccines","url":"/en-us/company/infectious-diseases/vaccines/","nodes":[],"isActive":false},{"title":"Flu","url":"/en-us/company/infectious-diseases/flu/","nodes":[],"isActive":false},{"title":"Shingles (Herpes Zoster)","url":"/en-us/company/infectious-diseases/shingles-herpes-zoster/","nodes":[],"isActive":false},{"title":"RSV (Respiratory Syncytial Virus)","url":"/en-us/company/infectious-diseases/rsv-respiratory-syncytial-virus/","nodes":[],"isActive":false},{"title":"Meningitis","url":"/en-us/company/infectious-diseases/meningitis/","nodes":[],"isActive":false}],"isActive":false}],"isActive":false,"promos":[{"text":"Global Outstanding people","image":{"src":"/media/kjtduuwb/20250115-extra-6-phl-small.jpg?width=329&height=185&format=webp&quality=100&v=1dbe12238ee2370&hmac=2ef3f6f97d5f1b7f7620eb52fb06639a23e819c47ca25dec024ddd025f705ea1","alt":"Two people walking in an office","darkModeSrc":"/media/kjtduuwb/20250115-extra-6-phl-small.jpg?width=329&height=185&format=webp&quality=90&v=1dbe12238ee2370&hmac=8fed218c6c7076c57c4d14a200a2b057b55f9c61e95d19399176255bc9baf00b"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/company/outstanding-people/","target":"_blank","openInNewWindowText":"Opens in a new window"}},{"text":"Global policy positions","image":{"src":"/media/diaofnw2/20250115-extra-14-phl.jpg?width=329&height=185&format=webp&quality=100&v=1dbe122233e8880&hmac=2843adf64f40a5bf3de75b028bccdd6f7e7ad0b367dd95d1ef0d77dbbbd245d1","alt":"An employee attending an online meeting","darkModeSrc":"/media/diaofnw2/20250115-extra-14-phl.jpg?width=329&height=185&format=webp&quality=90&v=1dbe122233e8880&hmac=102ff4fd1b2767c7376ad2347999e6f1009bb604978912c5b09cb32e38926b06"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/company/policy-positions","target":"_blank","openInNewWindowText":"Opens in a new window"}}]},{"tooltip":null,"hasBorderRight":false,"title":"Innovation","url":"/en-us/innovation/","nodes":[{"title":"Therapeutic areas","url":"/en-us/innovation/therapeutic-areas/","nodes":[],"isActive":false},{"title":"Technologies","url":"/en-us/innovation/technologies/","nodes":[],"isActive":false},{"title":"Clinical studies","url":"/en-us/innovation/clinical-studies/","nodes":[{"title":"Representative clinical trials","url":"/en-us/innovation/clinical-studies/representative-clinical-trials/","nodes":[],"isActive":false}],"isActive":false}],"isActive":false,"promos":[{"text":"Global pipeline","image":{"src":"/media/zr0acsx2/20281231-c1-innovation-um.jpg?width=329&height=185&format=webp&quality=100&v=1dc8fa7a9f728d0&hmac=2873b97da279e11f73602f7a9cba5364fde2775011021a467cd91bac8aed2463","alt":"A close-up shot of scientist's hands handling a vial","darkModeSrc":"/media/zr0acsx2/20281231-c1-innovation-um.jpg?width=329&height=185&format=webp&quality=90&v=1dc8fa7a9f728d0&hmac=207c4878e5f6b152b49bdd1d8256831c308ecc21effe806b26dbc91d412a6046"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/innovation/pipeline/","target":"_blank","openInNewWindowText":"Opens in a new window"}},{"text":"Global Behind the science magazine","image":{"src":"/media/vvwddvsg/gsk_tech_human_image_6k.jpg?width=329&height=185&format=webp&quality=100&v=1dcc04016a69c90&hmac=cf5a111e425b275e7ebdbab1c025eeb8ed09857c9edee9517b9bad6703278756","alt":"GSK Tech Human Image","darkModeSrc":"/media/vvwddvsg/gsk_tech_human_image_6k.jpg?width=329&height=185&format=webp&quality=90&v=1dcc04016a69c90&hmac=42086965489af81a1e9dd63c4b4e2f77e67b5b5632db5792095446137d265619"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/behind-the-science-magazine/","target":"_blank","openInNewWindowText":"Opens in a new window"}}]},{"tooltip":null,"hasBorderRight":false,"title":"Products","url":"/en-us/products/","nodes":[],"isActive":false,"promos":[]},{"tooltip":null,"hasBorderRight":true,"title":"Responsibility","url":"/en-us/responsibility/","nodes":[{"title":"Inclusion","url":"/en-us/responsibility/inclusion/","nodes":[],"isActive":false},{"title":"US charitable investments","url":"/en-us/responsibility/us-charitable-investments/","nodes":[{"title":"Charitable grants","url":"/en-us/responsibility/us-charitable-investments/charitable-grants/","nodes":[],"isActive":false}],"isActive":false},{"title":"Ethical standards","url":"/en-us/responsibility/ethical-standards/","nodes":[],"isActive":false}],"isActive":false,"promos":[{"text":"Access to medicines","image":{"src":"/media/q2cllvad/20271231-a1-careers-up.jpg?width=329&height=185&format=webp&quality=100&v=1dbe1221dd270f0&hmac=61c9705da6f36ac0e7cba8f547f7b5d85363406b25ff4bacd61aff9f50212908","alt":"A scientist checking experiment results in the lab","darkModeSrc":"/media/q2cllvad/20271231-a1-careers-up.jpg?width=329&height=185&format=webp&quality=90&v=1dbe1221dd270f0&hmac=ea90cef777b2a56b33cd9ac04981b2436c9374eda1cf2ea7fc3abb5a93e87d0c"},"link":{"text":"FEATURED WEBSITE","href":"https://www.gskforyou.com/","openInNewWindowText":null}},{"text":"Global Responsibility ","image":{"src":"/media/e5nbvffs/20250115-f4-ethical-standards-um.jpg?width=329&height=185&format=webp&quality=100&v=1dbe1221ed9f5e0&hmac=3b10e3accd9c56240ff039c54c418d8619989b0dded4c20ce1387060c7d734a5","alt":"A smiling scientist posing in the lab","darkModeSrc":"/media/e5nbvffs/20250115-f4-ethical-standards-um.jpg?width=329&height=185&format=webp&quality=90&v=1dbe1221ed9f5e0&hmac=60df253e2421316d25703ed5888efda432d001dd24362a79bd5cd7a21dfb6f45"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/responsibility/","target":"_blank","openInNewWindowText":"Opens in a new window"}}]},{"tooltip":null,"hasBorderRight":false,"title":"Media","url":"/en-us/media/","nodes":[{"title":"Press releases","url":"/en-us/media/press-releases/","nodes":[],"isActive":false},{"title":"Media contacts","url":"/en-us/media/media-contacts/","nodes":[],"isActive":false},{"title":"In Focus","url":"/en-us/media/in-focus/","nodes":[{"title":"Flu is a Family Affair","url":"/en-us/media/in-focus/flu-is-a-family-affair/","nodes":[],"isActive":false}],"isActive":false}],"isActive":false,"promos":[{"text":"Global press releases","image":{"src":"/media/svplhxgn/20271231-h2-visit-our-global-careers-site-link-um.jpg?width=329&height=185&format=webp&quality=100&v=1dbe12238bed610&hmac=8955fd4d2a54376e2bb8cccbd57ac9bac45c25c687fbd94389241becab45fd88","alt":"Two employees discussing work in the office","darkModeSrc":"/media/svplhxgn/20271231-h2-visit-our-global-careers-site-link-um.jpg?width=329&height=185&format=webp&quality=90&v=1dbe12238bed610&hmac=c6a836ccd89903607764c41c1e93f2d0293fdc5d988b6e03b23450d4deea8bba"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/media/press-releases/","target":"_blank","openInNewWindowText":"Opens in a new window"}}]},{"tooltip":null,"hasBorderRight":false,"title":"Careers","url":"/en-us/careers/","nodes":[{"title":"Search jobs","url":"/en-us/careers/search-jobs/","nodes":[],"isActive":false},{"title":"Life at GSK","url":"/en-us/careers/life-at-gsk/","nodes":[{"title":"Employment rights under federal law","url":"/en-us/careers/life-at-gsk/employment-rights-under-federal-law/","nodes":[],"isActive":false}],"isActive":false},{"title":"Experienced professionals","url":"/en-us/careers/experienced-professionals/","nodes":[{"title":"A career in oncology","url":"/en-us/careers/experienced-professionals/a-career-in-oncology/","nodes":[],"isActive":false},{"title":"A career in Boston","url":"/en-us/careers/experienced-professionals/a-career-in-boston/","nodes":[],"isActive":false}],"isActive":false},{"title":"Early careers","url":"/en-us/careers/early-careers/","nodes":[{"title":"Apprentices","url":"/en-us/careers/early-careers/apprentices/","nodes":[],"isActive":false},{"title":"Internships and co-ops","url":"/en-us/careers/early-careers/internships-and-co-ops/","nodes":[],"isActive":false},{"title":"Scientific leadership program","url":"/en-us/careers/early-careers/scientific-leadership-program/","nodes":[],"isActive":false},{"title":"Commercial development program","url":"/en-us/careers/early-careers/commercial-development-program/","nodes":[],"isActive":false}],"isActive":false},{"title":"Veterans at GSK","url":"/en-us/careers/veterans-at-gsk/","nodes":[],"isActive":false}],"isActive":false,"promos":[{"text":"Global how we hire","image":{"src":"/media/3u2dneiw/20271231-a3-contact-us-phl.jpg?width=329&height=185&format=webp&quality=100&v=1dbe12236d41d10&hmac=328fbee1bedb9f64e0987b415050708eee42af60fb57bb28c3525f0ad9887539","alt":"Three employees meeting in the office","darkModeSrc":"/media/3u2dneiw/20271231-a3-contact-us-phl.jpg?width=329&height=185&format=webp&quality=90&v=1dbe12236d41d10&hmac=623a6cede3a6a8305be8d41f686b04ebf0a0b96390547704eb65053a6b84f63f"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/careers/how-we-hire/","openInNewWindowText":null}},{"text":"Global graduate program","image":{"src":"/media/xrsfni0a/20281231-h4a-achieve-your-career-goals-up.jpg?width=329&height=185&format=webp&quality=100&v=1dbe1221e21c970&hmac=cc7acb6f8a166a2c48c403a01d54e007e1997acab9c92c5adf6b49341a656171","alt":"A smiling scientist posing in the lab","darkModeSrc":"/media/xrsfni0a/20281231-h4a-achieve-your-career-goals-up.jpg?width=329&height=185&format=webp&quality=90&v=1dbe1221e21c970&hmac=c6f3880c990298f0d58ebe0f38e2662f7616d2695bfcc1b3c9550db55a4ee053"},"link":{"text":"Spotlight on","href":"https://www.gsk.com/en-gb/careers/early-talent/future-leaders-graduate-programme","openInNewWindowText":null}}]}],"skipToContent":null,"skipToSearch":null,"typeaheadSearch":{"apiEndpoint":"api/search/typeahead?siteContainerId=1702","searchFieldPlaceholderText":"Enter a search term...","searchPage":"/en-us/search/","ariaLabel":"Submit form"},"ariaLabel":"Global navigation"},"footer":{"logo":null,"copyrightText":"

This is our US website, intended for US audiences only. Other market sites can be reached by visiting our location selector.

\n

© 2001-2026 GSK plc. All rights reserved. Trade marks are owned by or licensed to the GSK group of companies.

\n

GSK plc. Registered in England and Wales No. 3888792.

\n

Registered office: 79 New Oxford Street, London. United Kingdom. WC1A 1DG

","modernSlaveryStatement":null,"sections":{"socialMedia":{"columnTitle":"Follow us on:","socialMediaItems":[{"globalLink":{"text":null,"href":"http://www.linkedin.com/company/glaxosmithkline","target":"_blank","openInNewWindowText":"Opens in a new window"},"localLink":null,"ariaLabel":"Follow us on LinkedIn","customIcon":null,"showPopupMenu":false,"type":"LinkedIn"},{"globalLink":{"text":null,"href":"https://www.instagram.com/gskus?igsh=dDl0NjZmbmlia3F1","target":"_blank","openInNewWindowText":"Opens in a new window"},"localLink":null,"ariaLabel":"Follow us on Instagram","customIcon":null,"showPopupMenu":false,"type":"Instagram"},{"globalLink":{"text":null,"href":"https://www.threads.com/@gskus","target":"_blank","openInNewWindowText":"Opens in a new window"},"localLink":null,"ariaLabel":"Follow us on Threads","customIcon":null,"showPopupMenu":false,"type":"Threads"},{"globalLink":{"text":null,"href":"https://www.facebook.com/GSK","target":"_blank","openInNewWindowText":"Opens in a new window"},"localLink":null,"ariaLabel":"Follow us on Facebook","customIcon":null,"showPopupMenu":false,"type":"Facebook"},{"globalLink":{"text":null,"href":"http://www.youtube.com/GSK","target":"_blank","openInNewWindowText":"Opens in a new window"},"localLink":null,"ariaLabel":"Follow us on Youtube","customIcon":null,"showPopupMenu":false,"type":"Youtube"}]},"columns":[{"columnTitle":"GSK websites","links":[{"text":"GSK Global website","href":"https://www.gsk.com","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"Locations selector","href":"/en-us/locations/","openInNewWindowText":null},{"text":"Global Behind the science","href":"https://www.gsk.com/en-gb/behind-the-science/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"GSKPro for HCPs","href":"https://gskpro.com","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"ViiV Healthcare","href":"https://viivhealthcare.com/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"GSK study register","href":"https://www.gsk-studyregister.com/en/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"Business to Business","href":"/en-us/business-to-business-in-the-us/","openInNewWindowText":null},{"text":"Supplier website","href":"https://supplier.gsk.com/","target":"_blank","openInNewWindowText":"Opens in a new window"}]},{"columnTitle":"Quick links","links":[{"text":"Behind the science US edition","href":"/en-us/behind-the-science-us-edition/","openInNewWindowText":null},{"text":"Company","href":"/en-us/company/","openInNewWindowText":null},{"text":"Innovation","href":"/en-us/innovation/","openInNewWindowText":null},{"text":"Products","href":"/en-us/products/","openInNewWindowText":null},{"text":"Responsibility","href":"/en-us/responsibility/","openInNewWindowText":null},{"text":"Media","href":"/en-us/media/","openInNewWindowText":null},{"text":"Careers","href":"/en-us/careers/","openInNewWindowText":null}]},{"columnTitle":"Global investors","links":[{"text":"Shareholders","href":"https://www.gsk.com/en-gb/investors/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"Quarterly results","href":"https://www.gsk.com/en-gb/investors/quarterly-results/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"Financial reports","href":"https://www.gsk.com/en-gb/investors/financial-reports/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"Share price analysis","href":"https://www.gsk.com/en-gb/investors/dividend-and-share-price/","openInNewWindowText":null},{"text":"Product pipeline","href":"https://www.gsk.com/en-gb/innovation/pipeline/","target":"_blank","openInNewWindowText":"Opens in a new window"}]},{"columnTitle":"Get in touch","links":[{"text":"Contact us","href":"/en-us/contact-us/","openInNewWindowText":null},{"text":"Report a possible side effect","href":"/en-us/report-a-possible-side-effect/","openInNewWindowText":null},{"text":"GSK Speak up","href":"https://www.gsk.com/speakup","target":"_blank","openInNewWindowText":"Opens in a new window"}]}]},"bottomLinks":[{"text":"Accessibility","href":"/en-us/accessibility/","openInNewWindowText":null},{"text":"Digital sustainability","href":"/en-us/digital-sustainability/","openInNewWindowText":null},{"text":"Terms of use","href":"/en-us/terms-of-use/","openInNewWindowText":null},{"text":"Cookie policy","href":"/en-us/cookie-policy/","openInNewWindowText":null},{"text":"Privacy notice","href":"https://privacy.gsk.com/en-us/privacy-notice/","target":"_blank","openInNewWindowText":"Opens in a new window"},{"text":"About our ads","href":"/en-us/about-our-ads/","openInNewWindowText":null},{"text":"Sitemap","href":"/en-us/sitemap/","openInNewWindowText":null}],"continueToLink":{"text":"Advancing the Next Generation of Immuno-Oncology","href":"/en-us/behind-the-science-us-edition/advancing-the-next-generation-of-immuno-oncology/","openInNewWindowText":null,"continueTo":""},"legalApprovalText":""},"sharing":{"description":"In today’s remarkable field of Immuno-Oncology, there is still much yet to discover","og":[{"property":"og:title","content":"Immuno-Oncology: Integrating innovation into standard of care practice"},{"property":"og:description","content":"In today’s remarkable field of Immuno-Oncology, there is still much yet to discover"},{"property":"og:image","content":"https://us.gsk.com/media/l0hpeskg/scientist-3.jpg?width=600&format=webp&quality=100&v=1dbe12252ef8c50&hmac=4c261ac7e42161f9ecdd72af23410e55ab23b041b52438b5382b0c5f85373408"},{"property":"og:url","content":"https://us.gsk.com/en-us/behind-the-science-us-edition/immuno-oncology-integrating-innovation-into-standard-of-care-practice/"}],"twitter":[{"name":"twitter:card","content":"summary_large_image"},{"name":"twitter:site","content":"@gsk"},{"name":"twitter:title","content":"Immuno-Oncology: Integrating innovation into standard of care practice"},{"name":"twitter:description","content":"In today’s remarkable field of Immuno-Oncology, there is still much yet to discover"},{"name":"twitter:image","content":"https://us.gsk.com/media/l0hpeskg/scientist-3.jpg?width=600&format=webp&quality=100&v=1dbe12252ef8c50&hmac=4c261ac7e42161f9ecdd72af23410e55ab23b041b52438b5382b0c5f85373408"},{"name":"twitter:url","content":"https://us.gsk.com/en-us/behind-the-science-us-edition/immuno-oncology-integrating-innovation-into-standard-of-care-practice"}]},"stickyShare":{"href":"https://us.gsk.com/en-us/behind-the-science-us-edition/immuno-oncology-integrating-innovation-into-standard-of-care-practice/","pageTitle":"Immuno-Oncology: Integrating innovation into standard of care practice","shareText":"Share","newTabLinkText":"Opens in a new window","shareOnTwitterText":"Share on Twitter","shareOnLinkedInText":"Share on LinkedIn","shareOnFacebookText":"Share on Facebook"},"exitSitePreferences":{"popupEnabled":true,"title":"You are leaving our website","texts":"

The information you are about to be referred to may not comply with the local regulatory requirements. Further information relevant to the local environment is available from the company or via the Product Information.

","continueText":"Continue","cancelText":"Cancel","exclusionUrls":["https://www.gsk.com","https://www.facebook.com/GSK","http://doingmoreintheus.gsk.com/en-us/map-regions/","https://www.gsk.com/en-gb","https://www.gsk.com/en-gb/investors/quarterly-results/","https://www.gsk.com/en-gb/about-us/vaccines/why-you-don-t-outgrow-vaccination/","https://www.gsk.com/en-gb/behind-the-science/patients-consumers/eggs-in-manufacturing/","https://innovation.gsk.com/","http://doingmoreintheus.gsk.com/en-us/map-regions/north-carolina/doing-more-on-moore-drive-in-the-research-triangle-park/","http://doingmoreintheus.gsk.com/en-us/map-regions/pennsylvania/gsk-navy-yard-where-we-do-more-with-less/","https://www.gsk.com/en-gb/about-us/save-the-children-partnership","https://www.gskgrants.com","https://www.gskforyou.com/","http://fortherecord.payments.us.gsk.com","https://www.gsk-clinicalstudyregister.com/","https://www.gsk.com/en-gb/about-us/policies-codes-and-standards/","http://www.gsk.com/en-gb/about-us/policies-codes-and-standards/","https://www.gsk.com/en-gb/products/stiefel-dermatology/","https://www.gsk.com/en-gb/products/viiv-healthcare/","https://www.contactus.gsk.com/callback/index.html","https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=Home&entryPoint=adirect&messageType=Home","https://www.gsksource.com/pharma/content/gsk/source/us/en.html","http://www.msds-gsk.com/","https://www.gsk.com/en-gb/investors/shareholder-information/","http://www.gsk.com/en-gb/investors/","https://www.gsk.com/en-gb/investors/corporate-reporting/","https://www.gsk.com/en-gb/investors/product-pipeline/","http://www.gskgrants.com/","https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=Home&entryPoint=adirect&messageType=Home","https://www.gsk.com/media/2941/human-rights-statement-policy.pdf","http://www.gsk.com/media/280848/human-rights-statement-policy.pdf","http://www.gsk.com/en-gb/research/rd-locations/pharmaceuticals/","https://www.gsk.com/en-gb/business-to-business/","https://supplier.gsk.com/irj/portal/public?guest_user=SUP_GUEST_EN","https://www.gsk.com/en-gb/business-to-business/","https://supplier.gsk.com/irj/portal/public?guest_user=SUP_GUEST_EN","http://twitter.com/GSK","http://www.youtube.com/GSK","http://www.flickr.com/photos/glaxosmithkline","http://www.linkedin.com/company/glaxosmithkline","https://www.instagram.com/gsk/ ","http://www.gsk-clinicalstudyregister.com/","https://www.gsk.com/en-gb/media/press-releases/new-multi-country-survey-reveals-need-for-improved-awareness-around-long-term-impact-and-appropriate-use-of-corticosteroids-in-sle-management/","https://www.gsk.com/en-gb/behind-the-science/our-people/from-tv-to-tackling-lupus-why-alex-moved-from-media-to-medicine/","http://www.gskforyou.com/","http://us.gsk.com/en-us/behind-the-science/?tag=Corporate+responsibility","https://www.gskforyou.com/prescription-resource-assistance/immunology-respiratory/","https://www.contactus.gsk.com/callback.html","https://www.gsk.com/en-gb/about-us/governance/global-compliance/","https://www.gsk.com/en-gb/careers/physicians/","https://www.gsk.com/en-gb/careers/job-finder/","https://www.gsk.com/en-gb/contact-us/worldwide/","https://access.gsk.com/password/","https://access.gsk.com/selfservice/static/login.jsp?TYPE=33554433&REALMOID=06-c7edf5ec-5585-100d-83b1-84797f88fc89&GUID=&SMAUTHREASON=0&METHOD=GET&SMAGENTNAME=-SM-90R5K5a0NsTyKRhPyTIn3A3B5ovKkqcehflGRUrUNusjZdRaPY%2bWUozEFizs1bMg&TARGET=-SM-https%3a%2f%2fuksah%2egsk%2ecom%2fswh_uk_win_ns%2fcommunications%2femployee%2femployees%2ehtm","https://www.gsk.com/en-gb/responsibility/operating-responsibly/working-with-third-parties/","https://supplier.gsk.com/irj/portal/public?guest_user=SUP_GUEST_EN","https://ascend.cvmsolutions.com/Account/Login?client=gsk","https://twitter.com/GSKUS","https://twitter.com/GSK","https://www.gsk.com/media/5097/our-approach-to-responsible-business_sept-18.pdf","https://www.gsk.com/en-gb/responsibility/responsibility-reports-data/","https://www.gsk.com/media/2538/gsk-materiality-process.pdf","https://www.gsk.com/en-gb/responsibility/access-to-healthcare/","https://www.gsk.com/en-gb/responsibility/our-people/","https://www.gsk.com/en-gb/responsibility/environment/","https://www.gsk.com/en-gb/responsibility/operating-responsibly/","https://www.gsk.com/media/4552/our-code-of-practice.pdf","https://www.gsk.com/media/4552/our-code-of-practice.pdf#page=10","https://www.gsk.com/media/4552/our-code-of-practice.pdf#page=35","https://www.gsk.com/media/4552/our-code-of-practice.pdf#page=35","https://www.instagram.com/gsk/","https://twitter.com/gsk","https://twitter.com/gskus","https://www.youtube.com/GSK","https://www.gsk.com/en-gb/media/resource-centre/","https://www.gsk.com/en-gb/media/image-and-video-library/","https://www.gsk.com/en-gb/media/rss-feeds/","https://www.gsk.com/en-gb/investors/corporate-reporting/annual-report-2017/","https://www.gsk.com/en-gb/careers/experienced-professionals/business-operations/","https://www.gsk.com/en-gb/careers/experienced-professionals/engineering/","https://www.gsk.com/en-gb/careers/experienced-professionals/manufacturing-and-supply/","https://www.gsk.com/en-gb/careers/experienced-professionals/marketing-and-communications/","https://www.gsk.com/en-gb/careers/experienced-professionals/research-and-development/","https://www.gsk.com/en-gb/careers/experienced-professionals/sales/","https://www.gsk.com/media/5041/rd-update-slides-hal-barron.pdf","https://www.gsk.com/en-gb/careers/meet-our-people/","https://www.gsk.com/en-gb/responsibility/our-people/employee-volunteering/","https://www.gsk.com/en-gb/careers/postgraduate-opportunities/","https://gskearlytalent.avature.net/landingpage","https://www.gsk.com/en-gb/careers/apprentices-students-and-graduates/future-leaders-graduate-programme/","https://www.gsk.com/en-gb/responsibility/our-people/volunteer-stories/","https://www.gsk.com/en-gb/partnerships/bioelectronics-research-network/","https://www.gsk.com/en-gb/research/our-approach/open-innovation/","https://www.gsk.com/en-gb/careers/careers-search/?r=USA","https://www.linkedin.com/company/gsk-canada/","https://www.linkedin.com/company/gsk_consumer_healthcare_india/","https://www.linkedin.com/company/gsk-pharmaceuticals-india/","https://www.linkedin.com/company/glaxosmithkline-poland/","https://www.youtube.com/user/gskasiachannel/","https://www.youtube.com/channel/UChWuz9ZDceHYHXmJVJ4hF8Q","https://www.youtube.com/channel/UCN1XeWQWLVhFLHQwZl93jFQ","https://www.youtube.com/channel/UCwQyIfV4pLlsZGuN7fiZm2w","https://twitter.com/gsk_ar","https://twitter.com/GSK_Asia","https://twitter.com/gsk_conferences","https://twitter.com/gsk_au","https://twitter.com/GSK_DE","https://twitter.com/GSKCH_INDIA","https://twitter.com/GSK_IE","https://twitter.com/gsk_it","https://twitter.com/GSKScience","https://twitter.com/stiefel","https://www.gsk.com/en-gb/media/press-releases/karenann-terrell-appointed-chief-digital-technology-officer-gsk/","https://www.gsk.com/en-gb/behind-the-science/innovation/the-digitalisation-lab-bringing-the-digital-age-to-manufacturing/","https://www.gsk.com/en-gb/careers/meet-our-people/lindsay-rd-uk/","http://uk.gsk.com/en-gb/careers/apprenticeships/","https://www.gsk.com/media/4931/gsk-quick-facts.pdf","https://ie.gsk.com/ie/careers/apprenticeships/","http://au.gsk.com/en-au/careers/apprenticeships/","http://sg.gsk.com/en-sg/careers/","https://www.gsk.com/en-gb/contact-us/report-a-possible-side-effect/","https://gsk.i-sight.com/landing-page/","https://www.gskforyou.com/","https://jobs.gsk.com/en-us/jobs?keywords=RichmondConsumerHealthcareR%26D&page=1","https://jobs.gsk.com/en-us/jobs?page=1&location=Lincoln,%20NE,%20United%20States&woe=7&stretch=10&stretchUnit=KILOMETERS&keywords=manufacturing&sortBy=relevance","https://jobs.gsk.com/en-us/jobs?page=1&location=Carlisle,%20PA,%20United%20States&woe=7&stretch=10&stretchUnit=KILOMETERS&keywords=manufacturing&sortBy=relevance","https://jobs.gsk.com/en-us/jobs?page=1&location=East%20Durham,%20NY,%20United%20States&woe=7&stretch=10&stretchUnit=KILOMETERS&keywords=manufacturing&sortBy=relevance","https://us.gsk.com/en-us/media/press-releases/fda-approves-parp-inhibitor-in-first-line-monotherapy-maintenance-treatment-for-women-with-platinum-responsive-advanced-ovarian-cancer-regardless-of-biomarker-status/","https://privacy.gsk.com/en-us/privacy-notice/","https://www.gsk.com/en-gb/investors/corporate-reporting/annual-report-2020/","https://www.gsk.com/en-gb/careers/","https://www.gsk.com/en-gb/media/press-releases/gsk-delivers-fy-2021-reported-sales-of-34-billion-stable-at-aer-plus5-cer/","https://www.gsk.com/en-gb/investors/financial-reports/annual-report-2021/","https://www.gsk.com/media/7473/esg-performance-report-2021.pdf","https://www.gsk.com/en-gb/company/codes-standards-and-reports/","https://www.gsk.com/en-gb/investors/","https://www.gsk.com/en-gb/media/our-response-to-covid-19/","https://www.gsk.com/en-gb/behind-the-science-magazine/","https://www.gsk.com/en-gb/media/","https://www.gsk.com/en-gb/behind-the-science/","https://gskpro.com/","https://viivhealthcare.com/","https://www.gsk-studyregister.com/en/","https://gsk.supplierone.co/","https://www.gsk.com/en-gb/investors/financial-reports/","https://www.gsk.com/en-gb/investors/dividend-and-share-price/","https://www.gsk.com/en-gb/innovation/pipeline/","https://www.gsk.com/speakup","https://www.gsk.com/en-gb/company/outstanding-people/","https://www.gsk.com/en-gb/company/policy-positions","https://www.gsk.com/en-gb/research-and-development/our-approach-to-rd/","https://www.gsk.com/en-gb/innovation/partnerships/","https://www.gsk.com/media/8519/the-code-printable-version.pdf","https://www.gsk.com/en-gb/company/policy-positions/#","https://www.gsk.com/en-gb/innovation/therapeutic-areas/infectious-diseases/","https://www.gsk.com/en-gb/innovation/therapeutic-areas/hiv/","https://www.gsk.com/en-gb/innovation/therapeutic-areas/oncology/","https://www.gsk.com/en-gb/innovation/therapeutic-areas/immunology/","https://www.gsk.com/en-gb/innovation/therapeutic-areas/opportunity-driven/","https://www.togetherwithgskoncology.com/","https://www.gsk.com/en-gb/behind-the-science/looking-deeper-into-lupus/","https://gateway.on24.com/wcc/eh/3471076/Patient+Engagement+Hub","https://www.gsk.com/en-gb/behind-the-science/following-the-science-of-oxygen-to-discover-solutions-for-anaemia/","https://www.multivu.com/players/English/8857131-gsk-ask2bsure-meningitis-b-vaccination/","https://www.gsk.com/en-gb/innovation/rd-locations/","https://www.gsk.com/en-gb/innovation/research-and-development-approach/","https://www.gsk.com/en-gb/innovation/research-and-development-approach/","https://www.gsk.com/en-gb/innovation/","https://www.gsk.com/en-gb/behind-the-science/mrna-messenger-ribonucleic-acid-disrupting-the-field-of-vaccinology/","https://www.gsk.com/en-gb/behind-the-science/inside-the-vaccine-factory-of-the-future/","https://www.gsk-studyregister.com/","https://www.gsk.com/en-gb/responsibility/global-health-and-health-security/","https://www.gsk.com/en-gb/responsibility/pricing-and-access/","https://www.gsk.com/en-gb/responsibility/global-health-and-health-security/","https://www.gsk.com/en-gb/responsibility/diversity-equity-and-inclusion/","https://www.gsk.com/en-gb/responsibility/environmental-sustainability/","https://www.gsk.com/en-gb/responsibility/product-governance/","https://www.gsk.com/en-gb/responsibility/ethical-standards/","https://www.gsk.com/media/8518/policies-and-standards.pdf","https://www.gsk.com/en-gb/company/governance/compliance/","https://www.gsk.com/en-gb/responsibility/ethical-standards/working-with-third-parties/","https://www.gsk.com/en-gb/responsibility/ethical-standards/public-policy-and-patient-advocacy/","https://www.gsk.com/en-gb/responsibility/ethical-standards/human-rights/","https://www.gsk.com/en-gb/responsibility/ethical-standards/use-of-animals/","https://www.gsk.com/en-gb/responsibility/ethical-standards/engaging-with-healthcare-professionals/","https://www.gsk.com/en-gb/media/press-releases/","https://annualreport.gsk.com/","https://www.gsk.com/en-gb/media/media-contacts/","https://www.gsk.com/en-gb/media/media-library/","https://www.gsk.com/en-gb/media/social-media/","https://www.gsk.com/en-gb/media/our-response-to-the-situation-in-ukraine/","https://jobs.gsk.com/en-us/jobs?keywords=%23ApprenticeUS&location=&lang=en-us","https://www.gsk.com/en-gb/behind-the-science/advancing-the-next-generation-of-immuno-oncology/","https://www.gsk.com/en-gb/behind-the-science/synthetic-lethality-outmanoeuvring-the-cancer-genome/","https://www.gsk.com/en-gb/media/press-releases/gsk-and-lyell-immunopharma-join-forces-to-develop-the-next-generation-of-cancer-cell-therapies/","https://jobs.gsk.com/en-us/jobs?keywords=oncology&page=1","https://jobs.gsk.com/en-us/jobs?keywords=oncology&page=1","https://www.gsk.com/en-gb/research-and-development/our-pipeline/","https://jobs.gsk.com/en-us/jobs?keywords=%23WYARD2022&location=&lang=en-us","https://jobs.gsk.com/en-us/jobs?keywords=%23WYAcommerical2022&lang=en-us&sortBy=relevance&page=1","https://jobs.gsk.com/en-us/jobs?keywords=%23WYAGSC2022&lang=en-us&sortBy=relevance&page=1","https://jobs.gsk.com/en-us/jobs?lang=en-us&sortBy=relevance&page=1&location=United%20States&woe=12&stretchUnit=MILES&stretch=10","https://www.gsk.com/media/8520/the-code-presentation-version.pdf","https://www.gsk.com/en-gb/careers/featured-careers/","https://www.gsk.com/en-gb/careers/how-we-hire/","https://www.gsk.com/en-gb/careers/our-global-and-regional-hubs/","https://www.gsk.com/en-gb/careers/how-we-hire/frequently-asked-questions/","https://supplier.gsk.com/irj/portal/public","http://www.gsk.com/en-gb/contact-us/worldwide/","https://www.gsk.com/en-gb/contact-us/report-a-possible-side-effect/enquiries-privacy-notice/","https://gskpro.com/en-us/","https://gskpro.com/","https://gskpro.com","https://www.gsk.com/en-gb/responsibility/esg-resources/","http://www.gskfunding.com/","https://www.gsk.com/en-gb/behind-the-science-magazine/prevention-best-medicine-disease-patients/","https://www.gsk.com/en-gb/behind-the-science-magazine/men-women-gender-diversity-clinical-trials/","https://www.gsk.com/en-gb/behind-the-science-magazine/maps-technology-new-age-vaccine-development-infectious-diseases/","https://www.gsk.com/en-gb/investors/speeches-and-presentations/","https://www.gsk.com/en-gb/responsibility/environment/climate/","https://contactus.gsk.com/","https://gsk.connectr.co.uk/getahead/","https://www.linkedin.com/company/gsk/","https://x.com/GSKUS?mx=2","https://www.facebook.com/GSK/","https://jobs.gsk.com/?lang=en-us&previousLocale=en-US","https://jobs.gsk.com/en-us/jobs?keywords=%23USCommercialDevelopmentProgram&page=1&sortBy=relevance?keywords=%23USCommercialDevelopmentProgram&page=1&sortBy=relevance&location=United%20States","https://jobs.gsk.com/?lang=en-us&previousLocale=en-US","https://jobs.gsk.com/en-us/jobs?keywords=&location=&lang=en-us?keywords=%23ApprenticeUS2026&page=1&sortBy=relevance&location=United%20States&stretch=10&stretchUnit=MILES?keywords=%23ApprenticeUS2025%20&page=1&sortBy=relevance&location=United%20States","https://www.vaccinetrack.com/Trend?tab=gap&vaccine=9&timePeriod=2021","https://jobs.gsk.com/en-us/jobs?keywords=&location=&lang=en-us","http://tinyurl.com/mrt9buj2","https://jobs.gsk.com/en-gb/jobs?location=Massachusetts,%20United%20States&locations=Boston,Massachusetts,United%20States%7CCambridge,Massachusetts,United%20States%7CWaltham,Massachusetts,United%20States&page=1&stretch=10&stretchUnit=MILES&woe=8","https://jobs.gsk.com/en-us/jobs?keywords=%23USCommercialDevelopmentProgram&sortBy=relevance&page=1&location=United%20States&woe=12®ionCode=US&stretchUnit=MILES&stretch=50","https://jobs.gsk.com/en-us/jobs?keywords=%23USCommercialDevelopmentProgram&page=1&sortBy=relevance&location=United%20States?keywords=%23ApprenticeUS&location=&lang=en-us","https://x.com/GSKUS","https://ourwayforward.com/content/dam/brs-pharma-us/ourwayforward-dtc/en_US/pdfs/oc-patient-discussion-guide.pdf","https://gsk.public.reportum.com/","https://password.gsk.com/password/","https://uksah.gsk.com/swh_uk_win_ns/communications/employee/employees.htm","https://www.vaccinetrack.com/Trend?tab=gap&timePeriod=2022&timePeriod2=2021","https://gskvaccination.com/","https://jobs.gsk.com/en-gb/jobs?lang=en-gb&page=1&location=Massachusetts,%20United%20States&woe=8&stretchUnit=MILES&stretch=10&locations=Boston,Massachusetts,United%20States%7CCambridge,Massachusetts,United%20States%7CWaltham,Massachusetts,United%20States&utm_source=direct&utm_campaign=25453&utm_medium=symphonytalent-misctags&utm_term=43516_Boston%20In-House","https://dontbeembarrassed.com/","https://www.vaccinetrack.com","https://scienceinthesummer.fi.edu/","https://jobs.gsk.com/en-gb/jobs?location=United%20States&locations=Boston,Massachusetts,United%20States%7CCambridge,Massachusetts,United%20States%7CWaltham,Massachusetts,United%20States&page=1&stretch=10&stretchUnit=MILES&woe=8","https://us.gsk.com/en-us/media/press-releases/julie-bowen-and-ty-burrell-team-up-with-gsk-to-raise-awareness-about-meningitis-risks-for-teens-and-young-adults/","https://us.gsk.com/en-us/contact-us/","https://jobs.gsk.com/gb/en/search-results?m=3&keywords=%23ApprenticeUS2026","https://jobs.gsk.com/gb/en/search-results?m=3&keywords=Oncology","https://jobs.gsk.com/gb/en/ih-boston-all"]},"settings":{"optionalStylesheetLink":null,"themeColorHexCode":null,"headerLogoLightTheme":null,"headerLogoDarkTheme":null,"footerLogo":{"src":"https://us.gsk.com/media/kzafk31i/gsk-logo.png?width=104&format=webp&quality=100&v=1dbe12293a58ec0&hmac=a25f7108d09d8a8b732fbd04251a2fa28e97f61e629cff7623307613eeca2cd3","alt":"Gsk Logo (1)","darkModeSrc":"https://us.gsk.com/media/kzafk31i/gsk-logo.png?width=104&format=webp&quality=90&v=1dbe12293a58ec0&hmac=f91ed576717ab1f54deea0aaa180f5beb38518837d85f98823323fde477e1f38"},"scripts":[{"pageLocation":"Top","text":" \n"}],"globalWebsiteLink":{"text":"Global","href":"https://www.gsk.com","target":"_blank","openInNewWindowText":"Opens in a new window"},"googleMapsApiKey":"AIzaSyA2QMg4Ww6djPKb7b9BraQn4kgJmDaLblg","textToSpeechApiKey":"70ab0a79-1d92-4286-86d2-abdd71cc785c","bingVerificationCode":"","googleAnalytics":"","siteTitle":" | GSK US"},"pageSettings":{"disableBackToTopButton":false,"backToTopButtonText":"Back to top","robotsNoFollow":false,"robotsNoIndex":false,"canonicalUrl":"https://us.gsk.com/en-us/behind-the-science-us-edition/immuno-oncology-integrating-innovation-into-standard-of-care-practice/"},"tealiumSettings":{"enabled":false,"data":""},"entryPopup":null,"protectedPage":false,"schema":null}